Recent reverse aging research projects are reporting strong indicators of success. This is true of several scientific approaches to extending life and slowing the aging process. Researchers who study aging accept that extending the human lifespan to age 115 is likely.
Earlier reverse aging research taught us that our lifestyle habits could help us add years to our lives. We cannot be certain we will live longer but we can see our improvement in the mirror after a few weeks.
Scientists design experiments to significantly increase the lifespan of animals. They intend to apply the discoveries that work to human beings. There is a buzz of excitement around several experiments with mice, flies, and worms because they show strong indicators of longevity success.
1. Researchers proved that caloric restriction could extend the lifespan of rats by 50%. This was a landmark discovery because it proved longevity could be extended artificially.
2, Scientists also observed that chilled flies live longer than flies living in normal conditions. The theory explaining this has something to do with colder temperatures slowing metabolism.
3. In 1983 Michael Klass discovered that the nematode worm C. elegans could be manipulated to live longer. Later, Cynthia Kenyon of the University of California, San Francisco has extended these worms’ lives up to 10 times.
These initial breakthroughs indicated that it could be possible to intervene with aging scientifically.
The challenge has been converting the success with animals to humans.
A Decade Long Explosion of Positive Indicators
Several studies have reached the point in successful outcomes that they have started or are ready to begin human trials.
1. Researchers from the Salk Institute for Biological Studies in California reprogramed the cells of aging mice by using induced pluripotent cells. A pluripotent stem cell is a cell that can develop into any of the cell types that make up the body. Embryonic stem cells are considered pluripotent. As the embryo grows, its cells become specialized and lose the ability to become any kind of cell. Researchers found that the mice in this study whose cells had been reprogrammed lived 30% longer than the non-reprogrammed control group.
Scientists induced stem cells from adult cells in this study. The scientists reprogrammed skin cells to an embryonic state. This procedure allows doctors to use the patient’s own adult stem cells to return their bodies to a more youthful state.
2. Researchers at CalTech and UCLA developed a method to repair the mutant DNA that can cause cells to age and die. Cells typically contain two types of DNA found in the mitochondria – normal mtDNA and mutant mtDNA. The study targeted mutant mtDNA for mitophagy. “Mitophagy” is a process that breaks down and recycles mitochondria in order to prevent the aging process.
The team was successful in increasing mitophagy activity in a fruit fly. They noted a distinct reduction of mutant mtDNA in its muscle cells. The team’s next step is to determine if similar results can be accomplished in humans. The giant leap forward came when the researchers were able to target and adjust a single gene. This precise specialization eliminates unintended consequences and negative side-effects when humans undergo the treatment.
3. The National Institute of Aging found that combining and injecting preexisting drugs could extend the lifespan and delay age-related health issues in mice. The study focused on senescent cells. A senescent cell is an aged cell that no longer divides.
These cells do not perform well. the number of senescent cells increases with age. When these cells are present in large numbers, they can diminish overall cellular function. The Institute of Aging researchers used Dasatinib, a drug used to treat leukemia and quercetin, a plant pigment used as a food supplement to reduce allergic responses or boost immunity, in their study conducted on mice.
When treated with the medications, researchers found that senescent cells were selectively killed. The deterioration of the speed and mobility of the mice significantly decreased. In fact, naturally aging mice treated with the drugs in the study lived 36% longer than their control group counterparts.
If similar results can be replicated in humans, it would mean that we already have available drugs that could reverse aging and lengthen our lifespans.
4. Anti-Aging Pills: Treating Age With Medication
Researchers from the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School published a study where scientists used nicotinamide adenine dinucleotide (NAD+) to reverse the signs of aging in mice.
NAD+ is a molecule found in cells which is crucial for maintaining healthy cell function and regulating cellular aging. In the experiment, the scientists put a few drops of NAD+ into the mice’s water. Within hours, levels of NAD+ in their cells had risen significantly. Within a week, the tissues of the NAD+-fed mice had reversed to youthful levels.
A human trial was conducted in November 2017, which showed similarly promising results. NAD+ could become a reverse aging pill that produces these effects for people too.
5. Albert Einstein College of Medicine has received the first FDA approval for a clinical trial targeting aging as a disease. Until now, studies were devoted to individual diseases. Dr. Nir Barzilai, Director of the institute, successfully argued that the major risk for heart disease, diabetes, Alzheimer s and cancer is aging. There is a thousandfold increase in the likelihood that someone will die from one of these diseases at 80 than at 30.
The clinical trial is for a drug that was FDA approved 60 years ago, Metformin. Metformin is a safe, cheap, generic drug that is used to treat diabetes. However, worms and mice live longer in the lab when they are given Metformin. It has also been established that Metformin prevents cardiovascular disease.
Diabetics who are taking it, live longer than their non-diabetic partners who are not. The trial will determine if metformin protects from all of the age-related diseases. If the clinical trials are successful, we could have our first FDA approved as an age-reversal pill.
This is by no means a comprehensive list of all the reverse aging research that is happening now. These studies do represent the direction of research toward developing new pills or medical treatments. The recent success so many projects have experienced has led to a dramatic increase in funding available for age-reversal projects.
Age-Reversal is Getting Capitalized
Juvenescence: Investing in the Age of Longevity, the new book by Jim Mellon and Al Chalabi is a layman’s guide to longevity. It investigates the new technologies and explains how to benefit from the life-extending technologies both personally and professionally. It helps readers unravel the science, offers ideas on potential investment and reveals the views of the key opinion leaders. I recommend it for everyone who wants to be healthy and wealthy!
Billionaire Jim Mellon, one of the authors, is also one of the investors in the metformin clinical trials. Mellon has investments in nine biotech companies including Juvenescence AI which is focused on developing drugs that were discovered by Artificial Intelligence.
Juvenescence Limited is focused on enabling therapies to increase healthy human longevity. The team at Juvenescence Ltd. believes that recent advances in science have greatly improved our understanding of the biology of aging and seeks to develop therapeutics with the possibility of slowing, halting or potentially reversing elements of aging. Juvenescence will create or invest in new companies with aging or age-related therapeutics, in-license compounds from academia or industry, or engage in joint ventures to develop therapeutics for longevity.
Juvenescence Ltd. invested $3 million in LyGenesis, a company where scientists hope to inject liver cells into a patients’ lymph nodes and grow miniature livers there. This will eliminate the wait for a liver transplant.
Investments have gone to Insilico Medicine, a company applying machine-learning techniques to drug discovery. A joint venture between Insilico Medicine and Juvenescence AI is working to develop a “senolytic” drug that helps the body clear out cells that have stopped dividing and can damage other cells.
When commenting on all that has happened in the last seven years, Dr. Mellon states, “artificial intelligence — which didn’t exist in 2012 — is now very much in the frame for the development of new compounds. A cure for hepatitis C did not exist in 2012. Now, if you’ve got the money — and even if you don’t have the money, because drugs are coming down in price — you can be cured of hepatitis C. Cancer immunotherapy did not exist in 2012, and is fast becoming the standard of care in blood cancers and will ultimately become as important in solid tumors as well, improving cancer survival rates by a dramatic amount. And lastly, most importantly, CRISPR gene editing did not exist in 2012.”
All of these advances give confidence that dramatic life extension will happen. That confidence is being backed by investment capital worldwide as described in Juvenescence: Investing in the Age of Longevity.
In contrast to our bright future, today’s life expectancy is not advancing at the pace it did in the 1950s.
Life Expectancy in the U.S. is Dropping.
The drop in our national life expectancy has come as a result of the high number of opioid deaths that kill the young as well as the old. The improvements in life-expectancy came as a result of scientific discovery, better sanitation, better nutrition, better workplace safety, etc. Now in spite of advances, there are some who do not benefit from healthy advantages because of poverty and lack of education and lack of health coverage.
Advances in biology will make life better for everyone. Jim Mellon says, “The question then becomes: who benefits, and who doesn’t? And the answer is that a drug that will probably add eight years to average life expectancy is metformin. That will be available to everyone. There will be no one who can’t afford to take metformin. It will not be elite haves vs. have-nots”.
The advances in science and the economic climate will not be subject to politics. “So if you think about the manias that we’ve had in the last two or three years — cryptocurrencies and marijuana being the most recent and obvious ones — the fact that the science of longevity or juvenescence is catching up with the aspiration of ultra-long life, and is genuine, could actually lead to the biggest stock market mania of all time.” Jim Mellon,
The science is already headed for approval. Universities, corporations, and joint venture teams are already planning product launches and marketing campaigns. A longer, healthier, more active and productive lifespan is just around the corner. We still have to overcome the health traps and challenges that are a part of everyday life.
The Bridge to Age 115
We know that if we fully applied our current level of knowledge and biochemistry technology, a good number of us could live to age 115. We are also aware of the diseases that are most likely to prevent us,
COPD (chronic obstructive pulmonary disease)
We have the ability to minimize the risk of these diseases with our choices. There is a lot that we can do as we wait for drugs that can rid our bodies of senescent cells or the pill that will insulate us from old age diseases.
We have more life-determining power than any generation in history through our ability to make lifestyle choices. Choosing better means making changes. Age-Reversal coaching can help facilitate those changes.
The Age Reversology Lifestyle
Age-Reversology is how we can remain youthful and vital as treatments and drugs to complete clinical trials, go through FDA approval and eventually become affordable. Age-Reversology is about lifestyle choices that are based on science-backed best practices.
Looking and feeling young is the result of having healthy cells. Our cells only need five things to be healthy.
Reversing the bodies biological age is a Mind/Body/Spirit undertaking. We begin with a ‘few best practices” for giving our cells what they need. After supporting the body, we discover that several of our “aging issues” disappear in 30 days or less. If you would like recommendations for the first 30 days of your age-reversology lifestyle, please let me know in the comment section below
Please let me know if you found this information beneficial or if you have any questions in the comment section below.
May you Live 100 Years in Peace & Prosperity!